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Projects
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The major goal is to use environmental survey, laboratory experimental study and mathematic modeling to investigate the role of free DNA and biofilms in the spread of antibiotic resistance in surface water and drinking water.
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The overall goal of this study is to use DNA-based molecular techniques to better understand the ecological structure of multi-species biofilm development within the human body. We will use biofilms formed in vivo in urinary catheters as our model system for studying this process.
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Characterization of microbial ecology in metal removal fluids and associated biofilms to determine the role of biofilms in MRF-related hypersensitive pneumonitis among workers in automobile plants.
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The major goal is to elucidate the role of intrauterine microbial infections and biofilm formation in adverse birth outcomes.
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The major goal is to elucidate the molecular mechanisms responsible for the persistence of pathogens in drinking water distribution systems and the role of biofilms for the protection of pathogens.
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Antibiotic resistance is known to spread through person-to-person contact, but an environmental route of transmission may also be important in the current surge in antibiotic resistant infections. By mathematically modeling a person-environment-person pathway, we will provide insight into how antibiotic resistance emerges and is transported through the environment.
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Groups
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Leader: Chuanwu Xi (Ph.D.)
Research in the Xi Lab mainly focuses on biofilms, water quality, and human health. We use molecular and genomic tools to understand molecular mechanisms of persistence and resistance of pathogens in natural, engineered and industrial environments; transmission routes of pathogens from environments to hosts; and their impacts on health of general public and industrial workers. We are particularly interested.. >> more
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People from SPH
