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Projects
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This project is aimed at adapting a high-performance prototype portable gas chromatograph (GC) to the detection of volatile organic compounds (VOCs) in exhaled human breath. The instrument incorporates a detector consisting of an integrated array of chemiresistors (CR) coated with functionalized nanoparticles that respond differentially to sorbed vapors to produce a response pattern that aids in vapor.. >> more
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Thousands of different chemicals are released into our environment but few risk assessment tools are available to rapidly assess their potential to cause harm. Based on the premise that neurochemical changes precede overt neurotoxicity, our main objective is: to develop, validate, and use a practical in vitro/in vivo biomarker platform to screen the early effects of high-priority emerging contaminants.. >> more
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Environmental tobacco smoke (ETS) is a complex mixture of compounds collectively classified by the International Agency for Research on Cancer as a carcinogenic substance. The complexity of ETS and the presence of confounding sources of some ETS constituents in many environments have impeded accurate exposure assessments and have led to efforts to find surrogate measures of ETS contamination levels... >> more
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The health risks associated with long-term exposure to arsenic in drinking are still not well understood. Our research deals with the effects of arseninc exposure at elevated (in MIchigan) and high (Nadia Province, West Bengal, India) levels. The primary goal of the Michigan is to assess the effects of exposure to elevated levels of arsenic in drinking water as a risk factor in the development of.. >> more
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Exposure to metals, particularly lead, has been associated with the development of PD in a few but highly-suggestive studies. This topic has not yet been studied epidemiologically using state-of-the-art biological marker techniques for measuring metals exposure and accumulation.
Our research team has taken advantage of well-described, highly motivated and geographically convenient populations of PD.. >> more
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We are conducting a detailed exposure assessment within an ongoing epidemiological cohort taking place in a Chinese agricultural region. Along with other measures of exposure, the study utilizes biomarkers of pesticides that are commonly used in both China and the U.S.
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The aims of this project are to examine the association between ambient air pollution and sub-clinical markers of cardiovascular disease (heart rate variability, cardiac function, homocysteine) and to assess genes-environment and nutrient-environment interactions.
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This project seeks to specify the optimal quantities and types of high-surface-area adsorbent materials for the u-preconcentrator/focuser (uPCF) module of the WIMS uGC, and to define the optimal operating conditions for the uPCF.
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The Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project is a group of epidemiologic birth cohort studies with the mission of investigating the influence of environmental toxicant exposures on the development and future health of the fetus and infant.
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The Normative Aging Study (NAS) is a longitudinal study of 2,280 healthy male volunteers begun in Boston in the 1960s. Beginning in 1991 with an NIEHS R01 grant to study the impact of environmental lead exposure on risk of hypertension (NIEHS R01 ES 05257; PI: Howard Hu), NAS participants were invited to undergo bone and blood lead measurements. This project and a series of successful competitive.. >> more
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Our group conducted this study, the first ever to investigate associations between exposures to common ambient air pollutants and respiratory health status conducted among children in the South Durban industrial basin.
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This project aim to model the fate of nanoparticle in the body, based on measured kinetics of different nanoparticles and using PBPK approaches. This project is carried out in strong interaction with Dr. Martin Philbert's team, using measured value of peeble kinetics in animals. It also develops a new framework and re;ated methods to assess the Life Cycle impacts and benefits of nanomaterials.
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This project is aimed at characterizing and controlling exposures at petroleum refineries in India, and will develop capacity for advanced methods at the National Institute of Occupational Health in Meghaninagar, Ahmedabad. Currently there are 17 oil refineries producing a total of 127 million tons per year of petroleum products in India. The single private sector facility - and the largest -- is.. >> more
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Groups
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Leader: John Meeker (Sc.D., C.I.H.)
There is growing evidence and concern that reproductive and developmental health is impacted by our surrounding environment. Well-designed, hypothesis-based human studies are greatly needed to explore these relationships and inform risk reduction strategies. Exposure assessment is a vital component in environmental epidemiologic studies, yet the details of measuring exposure and the appropriateness.. >> more
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Leader: Edward T. Zellers (Ph.D.)
The assessment of human exposure to complex mixtures of natural and anthropogenic chemicals ranks among the most important global environmental health challenges. Our ability to meet evolving needs in this area relies critically on innovations in exposure science and technology. Advances that facilitate accurate, high-resolution measurements are integral to mankind's efforts to unravel the intricate.. >> more
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Leader: Rudy Richardson (Sc.D., D.A.B.T.)
The Richardson lab is concerned with understanding mechanisms of neurodegeneration or vascular disease mediated by age, genetics, and exposures to environmental agents. Knowledge gained about mechanisms is used to develop biomarkers or biosensors of exposure or disease and to enhance the process of risk assessment. We focus on examining interactions of small molecules with target proteins using kinetics.. >> more
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Leader: Niladri Basu (Ph.D.)
The Ecotoxicology Laboratory's research lies at the interface of human, wildlife, and ecosystem health. Our mandate is to better understand how neurotoxic pollutants affect our health by using traditional and innovative techniques. An eco-translational approach is taken whereby exposure-response-susceptibility relationships are studied at multiple tiers of biological organization (test tube - laboratory.. >> more
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Leader: Jerome Nriagu (Ph.D., D.Sc.)
Prof. Nriagu's research and teaching programs center around three main issues: (i) sources, behavior, fate and effects of metals in the natural and contaminated environments; (ii) environmental justice and disproportionate exposure of communities to environmental pollutants; and (iii) environmental health problems in the developing countries. His work includes applied laboratory and field studies and.. >> more
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Leader: Sung Kyun Park (Sc.D., M.P.H.)
Sung Kyun is interested in health effects of air pollution and metals exposure in aging populations. He has been working on the associations between air pollution, lead and subclinical cardiovascular outcomes, such as heart rate variability and homocysteine, using the Normative Aging Study. Sung Kyun is working on age-related diseases, such as impairment in renal function, age-related cataract and.. >> more
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Leader: J. Timothy Dvonch (Ph.D.)
Dr. Dvonch's work focuses on the exposure assessment, source identification, and health effects of air pollutants. He obtained a B.S. in Chemistry in 1992. In 1994, he earned an M.S. in Environmental Health Sciences, and subsequently a Ph.D. in Environmental Health Sciences in 1998. Dr. Dvonch collaborates on several large multi-disciplinary projects focused on environmental exposures and their related.. >> more
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People from SPH
