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Projects
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Exposure to metals, particularly lead, has been associated with the development of PD in a few but highly-suggestive studies. This topic has not yet been studied epidemiologically using state-of-the-art biological marker techniques for measuring metals exposure and accumulation.
Our research team has taken advantage of well-described, highly motivated and geographically convenient populations of PD.. >> more
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The major goal is to evaluate effect modification by iron metabolism genes (HFE, TF C2, HMOX-1) in the associations between chronic lead exposure and age-related diseases (cardiac function, renal function, age-related cataract, hearing loss) in a community-based cohort (the Normative Aging Study).
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Lead exposure poses a major environmental health problem in India. No direct studies have yet been performed in India to investigate the impact of lead exposure on outcomes such as neurobehavioral development. We propose to build upon a collaborative effort initiated during the proposed PI's work as a Senior Fulbright Scholar and work with colleagues at the Sri Ramachandra Medical College and Research.. >> more
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The aims of this project are to examine the association between ambient air pollution and sub-clinical markers of cardiovascular disease (heart rate variability, cardiac function, homocysteine) and to assess genes-environment and nutrient-environment interactions.
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In June of 2004, we established a new Center for Children's Environmental Health and Disease Prevention Research with support from the U.S. Environmental Protection Agency and the National Institute for Environmental Health Sciences. Our Center addresses the concerns of a community living in the Tar Creek Superfund site of Oklahoma - an area highly contaminated by metals (lead, cadmium, iron, manganese,.. >> more
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The Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project is a group of epidemiologic birth cohort studies with the mission of investigating the influence of environmental toxicant exposures on the development and future health of the fetus and infant.
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The Normative Aging Study (NAS) is a longitudinal study of 2,280 healthy male volunteers begun in Boston in the 1960s. Beginning in 1991 with an NIEHS R01 grant to study the impact of environmental lead exposure on risk of hypertension (NIEHS R01 ES 05257; PI: Howard Hu), NAS participants were invited to undergo bone and blood lead measurements. This project and a series of successful competitive.. >> more
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This project is developing the next-generation gas separation/ analysis system for the WIMS uGC. The three-chip microsystem is being designed to minimize mass to permit high-speed temp-erature programming and is ther-mally-isolated for very low operating power. The chips plug directly together to eliminate any external tubing, avoiding the cold-spots, dead volumes, and band broadening it can cause.. >> more
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Goal: To provide insight into toxicological mechanisms of PM-induced cardiopulmonary effects, particularly as they relate to susceptible subpopulations; and generate toxicological data to directly correspond to epidemiology and exposure assessment data from concurrent studies being conducted at one of the project locations.
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This project seeks to develop chemometric method to guide the development and allow the implementation of a miniaturized gas chromatography system for the detection of volatile organic chemicals in the workplace or general environment.
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The aim is to quantify partitioning of PBDEs into human placenta, extra-placental maternal/fetal membranes and umbilical cord blood in the general population.
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Prospective cohort study of chlorpyrifos manufacturing workers examining effects on the central and peripheral nervous systems, involving biological monitoring of urinary trichloropyridinol, serum cholinesterase, and PON genetic polymorphisms
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We aim to estimate global health impacts of trade by linking three actors: the producers of goods, the consumers of the goods, and the population impacted by the pollution (producers, consumers or a third party). Exchanges through trade (embodied pollution content) and multi-media pollutant transfer are considered on a global scale.
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The major goal is to elucidate the molecular mechanisms responsible for the persistence of pathogens in drinking water distribution systems and the role of biofilms for the protection of pathogens.
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The major goal is to use environmental survey, laboratory experimental study and mathematic modeling to investigate the role of free DNA and biofilms in the spread of antibiotic resistance in surface water and drinking water.
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The goal of this pilot project is to examine whether noise and lead have a joint effect on hearing threshold among community-residing elderly men. This study will implement a NIOSH generated job-exposure matrix to estimate historical noise exposure.
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The elucidation of mechanisms by which environmental chemicals modify uterine contractility using uterine smooth muscle cell cultures and and rat uterine strips suspended in muscle baths.
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This project is upgrading the waste management and control program for hospital and medical waste in Mozambique, a part of the JHPIEGO Mozambique Program in infection prevention and controlIn health care settings, occupational exposure to blood and body fluids puts health care providers at risk of infection with blood-borne pathogens, such as hepatitis B virus (HBV), hepatitis C virus (HCV) and HIV... >> more
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Creation of an adaptive multimedia model determining intake fractions at local (1km grid around the emission source), regional (200km grid within the continent of emission) and continental (world divided in continents) levels. Special emphasis is given to further develop modeling of exposure in the food chain linked to highest intake fractions and high level of uncertainties. This research builds up.. >> more
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This project develops a combined intake and physiologically based pharmacokinetic (PBPK) model to complement the regression model of the University of Michigan Dioxin Exposure Study (http://www.sph.umich.edu/dioxin/) and establish causal relationships. This work constitutes an important step in refining and building confidence in the statistical model. It will increase the model's ability to inform.. >> more
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Copper and most other metal ores are frequently found in association with high concentrations of crystalline silica. Respiratory diseases associated with silica exposures may include silicosis, silico-tuberculosis, and chronic obstructive pulmonary disease (COPD). Our group is investigating associations, among a cohort of active and retired copper miners, of exposure to respirable dust, and especially.. >> more
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Metal machining requires lubrication and dispersion of generated heat. Several distinct classes of metalworking fluids are used to accomplish these goals. Exposure these fluids is widespread in the automotive industry. Our study of acute respiratory effects associated with inhalational exposure to metalworking fluid aerosols in an automotive transmission plant resulted in a number of novel findings:.. >> more
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The burden of childhood asthma disproportionately affects children living in poverty and in urban centers, many of whom are minority ethnic groups. For those living in urban environments with high traffic densities, there is increasing concern about potential adverse respiratory health effects of exposure to diesel and other vehicular exhaust. Epidemiologic studies have shown associations between.. >> more
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Antibiotic resistance is known to spread through person-to-person contact, but an environmental route of transmission may also be important in the current surge in antibiotic resistant infections. By mathematically modeling a person-environment-person pathway, we will provide insight into how antibiotic resistance emerges and is transported through the environment.
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This study is investigating associations between exposures to common ambient air pollutants and respiratory health status (symptom prevalences and pulmonary function measures) in children living in both industrialized and non-industrialized areas of a large metropolitan city in South Africa. The South Durban Industrial Basin is a residential-industrial complex which arose during an era of racist (apartheid).. >> more
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The University of Michigan Center for Occupational Health and Safety Engineering (COHSE), a NIOSH-funded Education and Research Center (ERC), provides comprehensive professional and research training in Industrial Hygiene (IH), Occupational Health Nursing (OHN), Occupational Safety Engineering and Ergonomics (OSE), Hazardous Substances Academic Training (HSAT), Occupational Epidemiology (OE), and Pilot.. >> more
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This project aim to model the fate of nanoparticle in the body, based on measured kinetics of different nanoparticles and using PBPK approaches. This project is carried out in strong interaction with Dr. Martin Philbert's team, using measured value of peeble kinetics in animals. It also develops a new framework and re;ated methods to assess the Life Cycle impacts and benefits of nanomaterials.
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Our group has been continually funded by the Fogarty International Center since 1996 to strengthen capacity through training and research in Environmental and Occupational Health (EOH) in the 14-nation Southern Africa Development Community (SADC) region. The major strategy for sustainable capacity building is to leverage regional strengths in South Africa to support the development of academic research.. >> more
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Using the UNEP-SETAC toxicity model (USEtox), this project aims to recommended and interim characterisation factors for human health and freshwater ecotoxicity impacts. These developments that are essential for an improved comparative assessment of chemicals is carried out in direct collaboration with the model developers of CalTOX, IMPACT 2002, USES-LCA, BETR and EDIP.
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Groups
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Leader: Howard Hu (M.D., M.P.H., Sc.D.)
The Mission of the Michigan Metals Epidemiology Research Group (MERG) is to gain new insights into the impacts of exposure to potentially toxic metals that are of critical importance to public health and medicine by applying multi-disciplinary and novel methods of exposure assessment, genetics, nutrition, psychosocial factors and clinical measurements in epidemiologic studies of human populations around.. >> more
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Leader: Rudy Richardson (Sc.D., D.A.B.T.)
The Richardson lab is concerned with understanding mechanisms of neurodegeneration or vascular disease mediated by age, genetics, and exposures to environmental agents. Knowledge gained about mechanisms is used to develop biomarkers or biosensors of exposure or disease and to enhance the process of risk assessment. We focus on examining interactions of small molecules with target proteins using kinetics.. >> more
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Leader: Niladri Basu (Ph.D.)
The Ecotoxicology Laboratory's research lies at the interface of human, wildlife, and ecosystem health. Our mandate is to better understand how neurotoxic pollutants affect our health by using traditional and innovative techniques. An eco-translational approach is taken whereby exposure-response-susceptibility relationships are studied at multiple tiers of biological organization (test tube - laboratory.. >> more
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Leader: Chuanwu Xi (Ph.D.)
Research in the Xi Lab mainly focuses on biofilms, water quality, and human health. We use molecular and genomic tools to understand molecular mechanisms of persistence and resistance of pathogens in natural, engineered and industrial environments; transmission routes of pathogens from environments to hosts; and their impacts on health of general public and industrial workers. We are particularly interested.. >> more
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Leader: Craig Harris (Ph.D.)
Welcome to the laboratory research website of Dr. Craig Harris in the Department of Environmental Health Sciences, School of Public Health, at the University of Michigan.
The broad area of research interest in our laboratory involves studies to elucidate mechanisms of developmental toxicity and the mechanisms of developmental growth and differentiation that are controlled through redox.. >> more
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Leader: Sung Kyun Park (Sc.D., M.P.H.)
Sung Kyun is interested in health effects of air pollution and metals exposure in aging populations. He has been working on the associations between air pollution, lead and subclinical cardiovascular outcomes, such as heart rate variability and homocysteine, using the Normative Aging Study. Sung Kyun is working on age-related diseases, such as impairment in renal function, age-related cataract and.. >> more
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People from SPH
