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Projects
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Goal: To provide insight into toxicological mechanisms of PM-induced cardiopulmonary effects, particularly as they relate to susceptible subpopulations; and generate toxicological data to directly correspond to epidemiology and exposure assessment data from concurrent studies being conducted at one of the project locations.
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Goal: To demonstrate that short-term concentrated ambient coarse PM (CAP) inhalation (1) triggers pro-vasoconstrictive vascular dysfunctions related to (mediated by) CV autonomic imbalance; and (2) that these responses occur in African American and White adults alike following exposure to both urban and rural coarse PM; and (3) to elucidate the constituents/sources responsible for the CV responses.. >> more
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Goal: To conduct a pilot study to demonstrate the feasibility of investigating the effect of concentrated ambient PM2.5 inhalation upon coronary vascular function determined by cardiac positron emission tomography.
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We aim to estimate global health impacts of trade by linking three actors: the producers of goods, the consumers of the goods, and the population impacted by the pollution (producers, consumers or a third party). Exchanges through trade (embodied pollution content) and multi-media pollutant transfer are considered on a global scale.
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Work in the seafood industry provides an excellent model for IgE mediated occupational asthma caused by exposure to high molecular weight substances. Our current investigation of occupational allergic conditions among seafood processing workers in the Western Cape of South Africa exposed to both crustaceans and bony fish entails a comprehensive approach including novel exposure characterization methods.. >> more
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Metal machining requires lubrication and dispersion of generated heat. Several distinct classes of metalworking fluids are used to accomplish these goals. Exposure these fluids is widespread in the automotive industry. Our study of acute respiratory effects associated with inhalational exposure to metalworking fluid aerosols in an automotive transmission plant resulted in a number of novel findings:.. >> more
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This project aims to explore and better understand the source-to-body fate, exposure and body distribution of polybrominated diphenyl ethers (PBDEs) and PAHs. PBDEs are considered emerging contaminants of great concern due to both their toxicity and the rapidly rising levels found in human and in the environment. The idea is to couple multimedia fate and exposure models with physiologically-based pharmacokinetic.. >> more
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Using the UNEP-SETAC toxicity model (USEtox), this project aims to recommended and interim characterisation factors for human health and freshwater ecotoxicity impacts. These developments that are essential for an improved comparative assessment of chemicals is carried out in direct collaboration with the model developers of CalTOX, IMPACT 2002, USES-LCA, BETR and EDIP.
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Groups
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Leader: Edward T. Zellers (Ph.D.)
The assessment of human exposure to complex mixtures of natural and anthropogenic chemicals ranks among the most important global environmental health challenges. Our ability to meet evolving needs in this area relies critically on innovations in exposure science and technology. Advances that facilitate accurate, high-resolution measurements are integral to mankind's efforts to unravel the intricate.. >> more
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People from SPH
