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Projects
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The overarching goal of this healthy homes project is to reduce the burdens of asthma and lead poisoning among low-income children in the City of Saginaw. The objectives of the project include (A) use a proactive screening tool developed by the investigators to identify households with the highest hazards for asthma and childhood lead poisoning; (B) screen children in the identified household for.. >> more
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This research aims to better understand the emissions of PBDEs from residential buildings and to estimate emissions from urban sources into ambient air that may ultimately be deposited into the Great Lakes region
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The significance and consequences of co-exposure to lead and Plasmodium have not been well researched. This project deals with lead poisoning as a co-factor for malaria among young children in Nigeria and other African countries where the two morbidities are pandemic. The principal goals include (a) determine the relationships between lead exposure and prevalence of childhood malaria in areas of Nigeria.. >> more
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The goal of this pilot project is to examine whether noise and lead have a joint effect on hearing threshold among community-residing elderly men. This study will implement a NIOSH generated job-exposure matrix to estimate historical noise exposure.
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The major goal is to evaluate effect modification by iron metabolism genes (HFE, TF C2, HMOX-1) in the associations between chronic lead exposure and age-related diseases (cardiac function, renal function, age-related cataract, hearing loss) in a community-based cohort (the Normative Aging Study).
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The aim is to quantify partitioning of PBDEs into human placenta, extra-placental maternal/fetal membranes and umbilical cord blood in the general population.
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This project develops a combined intake and physiologically based pharmacokinetic (PBPK) model to complement the regression model of the University of Michigan Dioxin Exposure Study (http://www.sph.umich.edu/dioxin/) and establish causal relationships. This work constitutes an important step in refining and building confidence in the statistical model. It will increase the model's ability to inform.. >> more
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This partnership between UM and Centre for Environmental Chemistry in Obninsk, Russia will address the migration and impacts of persistent organic pollutants in the Arctic region.
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Lead exposure poses a major environmental health problem in India. No direct studies have yet been performed in India to investigate the impact of lead exposure on outcomes such as neurobehavioral development. We propose to build upon a collaborative effort initiated during the proposed PI's work as a Senior Fulbright Scholar and work with colleagues at the Sri Ramachandra Medical College and Research.. >> more
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This research aims to better understand the distribution of mobile BFRs in residential, commercial and industrial buildings and to estimate emissions from urban sources into ambient air that may ultimately be deposited into the Great Lakes region
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The objectives are to determine the mechanisms and downstream consequences of inflammatory responses in human gestational membranes exposed in vitro to environmental pollutants.
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Exposure to metals, particularly lead, has been associated with the development of PD in a few but highly-suggestive studies. This topic has not yet been studied epidemiologically using state-of-the-art biological marker techniques for measuring metals exposure and accumulation.
Our research team has taken advantage of well-described, highly motivated and geographically convenient populations of PD.. >> more
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In June of 2004, we established a new Center for Children's Environmental Health and Disease Prevention Research with support from the U.S. Environmental Protection Agency and the National Institute for Environmental Health Sciences. Our Center addresses the concerns of a community living in the Tar Creek Superfund site of Oklahoma - an area highly contaminated by metals (lead, cadmium, iron, manganese,.. >> more
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This project aims to explore and better understand the source-to-body fate, exposure and body distribution of polybrominated diphenyl ethers (PBDEs) and PAHs. PBDEs are considered emerging contaminants of great concern due to both their toxicity and the rapidly rising levels found in human and in the environment. The idea is to couple multimedia fate and exposure models with physiologically-based pharmacokinetic.. >> more
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The Normative Aging Study (NAS) is a longitudinal study of 2,280 healthy male volunteers begun in Boston in the 1960s. Beginning in 1991 with an NIEHS R01 grant to study the impact of environmental lead exposure on risk of hypertension (NIEHS R01 ES 05257; PI: Howard Hu), NAS participants were invited to undergo bone and blood lead measurements. This project and a series of successful competitive.. >> more
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This project aim to model the fate of nanoparticle in the body, based on measured kinetics of different nanoparticles and using PBPK approaches. This project is carried out in strong interaction with Dr. Martin Philbert's team, using measured value of peeble kinetics in animals. It also develops a new framework and re;ated methods to assess the Life Cycle impacts and benefits of nanomaterials.
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The determination of complex mixtures of toxic gases and vapors remains a challenging analytical problem of critical importance in human exposure assessments, industrial emission monitoring, biomedical surveillance and diagnosis, and homeland security. To address this problem, we are developing a wireless MEMS micro-GC (uGC) that includes a sample inlet with particulate filter, passive calibration-vapor.. >> more
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Investigating chemical exchange processes at the air-water interface.
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Thousands of different chemicals are released into our environment but few risk assessment tools are available to rapidly assess their potential to cause harm. Based on the premise that neurochemical changes precede overt neurotoxicity, our main objective is: to develop, validate, and use a practical in vitro/in vivo biomarker platform to screen the early effects of high-priority emerging contaminants.. >> more
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Creation of an adaptive multimedia model determining intake fractions at local (1km grid around the emission source), regional (200km grid within the continent of emission) and continental (world divided in continents) levels. Special emphasis is given to further develop modeling of exposure in the food chain linked to highest intake fractions and high level of uncertainties. This research builds up.. >> more
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This project first seeks to characterize the different redox environments that are established and maintained within the intact rat and mouse conceptus (embryo proper and associated extraembryonic membranes). Concentrations, redox potentials, and flux for redox couples that make up the major redox circuits such as glutathione (GSH)/glutathione disulfide (GSSG), cysteine (cys)/cystine (cySS), and thioredoxin-reduced.. >> more
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The Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project is a group of epidemiologic birth cohort studies with the mission of investigating the influence of environmental toxicant exposures on the development and future health of the fetus and infant.
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Groups
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Leader: Sung Kyun Park (Sc.D., M.P.H.)
Sung Kyun is interested in health effects of air pollution and metals exposure in aging populations. He has been working on the associations between air pollution, lead and subclinical cardiovascular outcomes, such as heart rate variability and homocysteine, using the Normative Aging Study. Sung Kyun is working on age-related diseases, such as impairment in renal function, age-related cataract and.. >> more
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Leader: Stuart Batterman (Ph.D.)
Our teaching and research address a wide range of topics in occupational, indoor and environmental settings. Topics include exposure assessment (especially for particulate matter and volatile organic compounds or VOCs); emerging contaminants in occupational, ecological and environmental settings (e.g., brominated flame retardants); biological monitoring (e.g., blood, breath); air quality monitoring.. >> more
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Leader: Olivier Jolliet (Ph.D.)
The Impact and Risk Modeling (iMod) laboratory aims to provide the scientific knowledge for assessing environmental risks and impacts of chemicals and of innovative technologies, in order to:
(1) Model population-based exposure and multi-pathways intake fractions for outdoor and indoor chemical emissions
(2) Assess individual and population body burdens and risks using physiologically based pharmacokinetic/dynamic.. >> more
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Leader: John Meeker (Sc.D., C.I.H.)
There is growing evidence and concern that reproductive and developmental health is impacted by our surrounding environment. Well-designed, hypothesis-based human studies are greatly needed to explore these relationships and inform risk reduction strategies. Exposure assessment is a vital component in environmental epidemiologic studies, yet the details of measuring exposure and the appropriateness.. >> more
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Leader: Peter Mancuso (Ph.D.)
Peter Mancuso is an interdisciplinary scientist whose research focuses on environmental factors that regulate pulmonary immune responses. He has used cellular, molecular and integrative biology to determine the impact of environmental influences such as obesity, malnutrition, and tobacco smoke exposure on alveolar macrophage and pulmonary innate immune responses to bacterial infection. He is a member.. >> more
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Leader: Jerome Nriagu (Ph.D., D.Sc.)
Prof. Nriagu's research and teaching programs center around three main issues: (i) sources, behavior, fate and effects of metals in the natural and contaminated environments; (ii) environmental justice and disproportionate exposure of communities to environmental pollutants; and (iii) environmental health problems in the developing countries. His work includes applied laboratory and field studies and.. >> more
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People from SPH
