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- Projects	:	3
- Group	:	1

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Projects

>> PBPK modeling to support the statistical analysis of the University of Michigan Dioxin Exposure Study

This project develops a combined intake and physiologically based pharmacokinetic (PBPK) model to complement the regression model of the University of Michigan Dioxin Exposure Study (http://www.sph.umich.edu/dioxin/) and establish causal relationships. This work constitutes an important step in refining and building confidence in the statistical model. It will increase the model's ability to inform.. >> more

>> Toxicokinetics of nanoparticles and their Life cycle impacts and benefits

This project aim to model the fate of nanoparticle in the body, based on measured kinetics of different nanoparticles and using PBPK approaches. This project is carried out in strong interaction with Dr. Martin Philbert's team, using measured value of peeble kinetics in animals. It also develops a new framework and re;ated methods to assess the Life Cycle impacts and benefits of nanomaterials.

>> Source to body burden modeling of PAHs and flame retardants toxic impacts

This project aims to explore and better understand the source-to-body fate, exposure and body distribution of polybrominated diphenyl ethers (PBDEs) and PAHs. PBDEs are considered emerging contaminants of great concern due to both their toxicity and the rapidly rising levels found in human and in the environment. The idea is to couple multimedia fate and exposure models with physiologically-based pharmacokinetic.. >> more

Groups

>> Jolliet Lab - Impact and Risk Modeling (iMod)

Leader: Olivier Jolliet (Ph.D.)

The Impact and Risk Modeling (iMod) laboratory aims to provide the scientific knowledge for assessing environmental risks and impacts of chemicals and of innovative technologies, in order to: (1) Model population-based exposure and multi-pathways intake fractions for outdoor and indoor chemical emissions (2) Assess individual and population body burdens and risks using physiologically based pharmacokinetic/dynamic.. >> more