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Projects
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Goal: To provide insight into toxicological mechanisms of PM-induced cardiopulmonary effects, particularly as they relate to susceptible subpopulations; and generate toxicological data to directly correspond to epidemiology and exposure assessment data from concurrent studies being conducted at one of the project locations.
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The aims of this project are to examine health effects of chronic cadmium exposure, especially pulmonary and renal functions and bone damage, in a subset of the Normative Aging Study, and to evaluate whether there exists smoking-dependent associations.
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Copper and most other metal ores are frequently found in association with high concentrations of crystalline silica. Respiratory diseases associated with silica exposures may include silicosis, silico-tuberculosis, and chronic obstructive pulmonary disease (COPD). Our group is investigating associations, among a cohort of active and retired copper miners, of exposure to respirable dust, and especially.. >> more
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The effects of coal dust exposure on the respiratory tract are complex. Long term work as a coal miner at relatively high exposures has been associated with the risk for pneumoconiotic X ray changes which may be accompanied by a restrictive pattern of pulmonary function. In addition, at perhaps lower exposures, coal mining is associated with chronic bronchitis and obstructive PFT changes. We conducted.. >> more
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The burden of childhood asthma disproportionately affects children living in poverty and in urban centers, many of whom are minority ethnic groups. For those living in urban environments with high traffic densities, there is increasing concern about potential adverse respiratory health effects of exposure to diesel and other vehicular exhaust. Epidemiologic studies have shown associations between.. >> more
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This study is investigating associations between exposures to common ambient air pollutants and respiratory health status (symptom prevalences and pulmonary function measures) in children living in both industrialized and non-industrialized areas of a large metropolitan city in South Africa. The South Durban Industrial Basin is a residential-industrial complex which arose during an era of racist (apartheid).. >> more
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Groups
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Leader: Peter Mancuso (Ph.D.)
Peter Mancuso is an interdisciplinary scientist whose research focuses on environmental factors that regulate pulmonary immune responses. He has used cellular, molecular and integrative biology to determine the impact of environmental influences such as obesity, malnutrition, and tobacco smoke exposure on alveolar macrophage and pulmonary innate immune responses to bacterial infection. He is a member.. >> more
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People from SPH
