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Dolinoy Lab - Environmental Epigenetics and Nutrition

Muna Nahar

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E-mail: msnahar@umich.edu

 

Summary

Muna is a pre-candidate in Toxicology at the School of Public Health Department of Environmental Health Sciences. Although born in Bangladesh, she was raised in Manchester, CT with her two younger siblings. Her college years were spent also in CT, where she conducted yeast genetics research focusing on the 2-micron plasmid under the direction of Dr. Scott Holmes. She graduated from Wesleyan University with Honors (BA) in 2009 with a double major in Molecular Biology & Biochemistry and Chemistry. She looks forward to participating in environmental epigenetics research in the Dolinoy-Rozek lab, focusing on Bisphenol A exposure on the human epigenome for her dissertation. In her free time, Muna enjoys baking, traveling, nature, and is open to any new experiences and adventures with friends (so just look for the girl in the tie-dyed lab coat in the 6th floor)!!!

Projects

>> In Utero Exposure to Bisphenol A: Effects on the Fetal Epigenome

The overall objective of this grant application is to identify species, dose, and tissue-specific epigenome-wide alterations following gestational exposure to bisphenol a (BPA), a high production volume chemical used in the manufacturing of polycarbonate plastics and epoxy resins, and to map developmentally labile epigenetic genes in order to facilitate human health risk assessment and human disease prevention, diagnosis, and treatment.... More >>

 

>> Environmental and Epigenomic Profiling of Pre-Adolescent Females in Rural Versus Urban Egyptian Populations (UM EHS Pilot Grant)

Pre-pubertal females are particularly vulnerable to environmental influence on the epigenome due to mammary gland growth and differentiation. Similarly, genetic variation, such as single nucleotide polymorphisms (SNPs), can modify the toxicokinetics of chemical uptake, distribution, and elimination. Our overarching hypothesis is that epigenetic and genetic differences contribute to interindividual variation in BPA and phthalate exposure profiles. Building upon ongoing epidemiological and exposure studies in Gharbiah, Egypt, the two specific aims of this pilot project are: 1) Characterize pre-adolescent female exposure ... More >>

 

>> Oxidative Stress

In collaboration with Crag Harris, this pilot project aims to investigate how chemical teratogens and nutritional deficits affect DNA methylation through oxidative stress and redox regulation.... More >>